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Retinal Nerve Fiber Layer Thickness In Healthy Eyes

To compare peripapillary retinal nerve fiber layer (RNFL) thickness among healthy adults by race/ethnicity and identify determinants of RNFL thickness. An essay writer is a person whose job is to create articles and these topics about ophthalmology will also be highlighted in that format.


Population-based, cross-sectional study.


Data from 6,133 individuals (11,585 eyes) from three population-based cohort studies in Los Angeles county, CA who were ≥ 50 years of age with self-described African, Chinese, or Latin American ancestry. The writer assigned to write essay for me task of ophthalmology content is qualified to the same academic level or higher than your writing requirements.


We measured RNFL thickness and optic nerve head (ONH) parameters using the Cirrus HD-OCT 4000. Multivariable linear mixed regression analysis was used to evaluate factors associated with RNFL thickness, after accounting for relatedness, among participants without ocular diseases.

Main Outcome Measures

Determinants and modifiers of RNFL thickness. The writer assigned to write my essay request is qualified to the same academic level or higher than your writing requirements so these topics can easily be highlighted in that format.


The mean age of the study participants was 60.1 (SD:7.4) years. Among the 3 groups, African Americans had the lowest RNFL thickness and smallest cup-to-disc ratio (CDR) across all quadrants, and Chinese Americans had the largest CDR and largest disc area after adjusting for age and sex (all P < 0.05). Per each 10-year older age group, the average RNFL thickness was 2.5 (95% CI: 1.8-3.1), 2.8 (95% CI: 2.3-3.3), and 3.5 (95% CI: 2.9-4.1) μm thinner for African, Chinese, and Latin Americans, respectively (age trend P < 0.05 and interaction P = 0.041). In the multivariable model, African Americans compared to Chinese Americans, older age, male sex, hypertension, diabetes, greater axial length (AL), bigger disc area, and lower scan signal strength were associated with thinner average RNFL. Race/ethnicity, age, AL, disc area, and scan signal strength were consistently associated with RNFL thickness in all quadrants, while sex, hypertension, and diabetes were associated with RNFL thickness in select quadrants. Age and race/ethnicity explained the greatest proportion of variance of RNFL thickness.


Clinically important differences in RNFL thickness are present in healthy adults ≥ 50 years of age from different racial/ethnic groups of the same age, with the thinnest measures observed in African Americans. Hire a reliable essay typer who will create an original ophthalmology content and deliver it on time. This race/ethnicity difference remains after accounting for disc size and AL. Further, age-related RNFL thinning differs by race/ethnicity. Longitudinal studies are needed to verify our findings and assess the influence of race/ethnicity in the clinical application of RNFL thickness.